Is infection with hypermutable Pseudomonas aeruginosa clinically significant?
نویسندگان
چکیده
منابع مشابه
Detection and susceptibility testing of hypermutable Pseudomonas aeruginosa strains with the Etest and disk diffusion.
Resistance development in Pseudomonas aeruginosa from chronically colonized cystic fibrosis (CF) patients has been linked to the presence of a high proportion of mismatch repair-deficient hypermutable strains. The detection of hypermutable strains by microbiology laboratories may be useful for establishing adequate antimicrobial therapies. In this work, we find that the Etest and disk diffusion...
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BACKGROUND In patients with cystic fibrosis (CF), the emergence of hypermutable Pseudomonas aeruginosa drives the selection of P. aeruginosa variants that are efficiently adapted to the inflamed lungs of these patients. OBJECTIVE To provide a detailed survey of adaptive changes in the physiology of P. aeruginosa during chronic lung infection in patients with CF. METHODS We performed a compa...
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Oxidative stress caused by chronic lung inflammation in patients with cystic fibrosis (CF) and chronic lung infection with Pseudomonas aeruginosa is characterized by the reactive oxygen species (ROS) liberated by polymorphonuclear leukocytes (PMNs). We formulated the hypothesis that oxidation of the bacterial DNA by ROS presents an increased risk for the occurrence of hypermutable P. aeruginosa...
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Hypermutable (HPM) strains of Pseudomonas aeruginosa have been found at high frequencies in cystic fibrosis (CF) patients in Europe. We report the results of testing for HPM frequencies, mutator genotype, and antimicrobial resistance of P. aeruginosa strains from Brazilian CF patients. A modified disk diffusion technique was used to quantify antibiotic-resistant subpopulations of an isolate, an...
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Editorial Lown et al. (1) report a significant advance in describing a new mechanism by which ingested nutrients may change exposure to drug therapy. Grapefruit juice was reported to increase plasma concentrations of felodipine and nifedipine when the drug was concurrently administered with grapefruit juice (2). The potential clinical importance of such an interaction was noted when cyclosporin...
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ژورنال
عنوان ژورنال: Journal of Cystic Fibrosis
سال: 2015
ISSN: 1569-1993
DOI: 10.1016/j.jcf.2014.09.011